Siyuan Ding, Ph.D.
Washington University in St. Louis - Assistant Professor, Department of Molecular Microbiology
“Immunogenicity and protective efficacy of rotavirus-ETEC dual vaccines”
Infectious diarrhea kills more children each day than AIDS, malaria, and measles combined. Rotavirus and enterotoxigenic Escherichia coli (ETEC) are the leading viral and bacterial agents of diarrhea in infants, respectively, causing over 300,000 deaths annually worldwide.
Current rotavirus vaccine efficacy is limited, and no licensed vaccine is available for ETEC. In a key technical advance, Dr. Ding’s lab developed highly efficient reverse genetics systems and constructed live-attenuated rotaviruses that encode an immunogenic subunit of the ETEC heat-labile toxin.
He will test the immunogenicity and protective efficacy of this rotavirus-ETEC dual vaccine candidate.
About Siyuan Ding
Dr. Siyuan Ding received his bachelor’s degree in Biological Science from Fudan University in Shanghai. He then received doctoral training at Yale University, working on hepatitis B virus and type III interferon signaling.
Dr. Ding then conducted postdoctoral training at Stanford University, studying rotavirus infection and intestinal immunity.
He started his independent research lab as an Assistant Professor at Washington University in St. Louis at the end of 2019.